WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:RNA degradation       ID:03018
C=71; O=2; E=0.18; R=11.35; rawP=0.0136; adjP=0.0238
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152520 NA PAN3 PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) 255967 ENSG00000152520
2  ENSG00000120699 NA EXOSC8 exosome component 8 11340 ENSG00000120699


Database:KEGG pathway       Name:Complement and coagulation cascades       ID:04610
C=69; O=2; E=0.17; R=11.68; rawP=0.0128; adjP=0.0238
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000009724 NA MASP2 mannan-binding lectin serine peptidase 2 10747 ENSG00000009724
2  ENSG00000117525 NA F3 coagulation factor III (thromboplastin, tissue factor) 2152 ENSG00000117525


Database:KEGG pathway       Name:Arginine and proline metabolism       ID:00330
C=54; O=2; E=0.13; R=14.93; rawP=0.0080; adjP=0.0238
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000135423 NA GLS2 glutaminase 2 (liver, mitochondrial) 27165 ENSG00000135423
2  ENSG00000072682 NA P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 8974 ENSG00000072682


Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=3; E=0.32; R=9.52; rawP=0.0040; adjP=0.0238
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100650 NA SRSF5 serine/arginine-rich splicing factor 5 6430 ENSG00000100650
2  ENSG00000079134 NA THOC1 THO complex 1 9984 ENSG00000079134
3  ENSG00000113649 NA TCERG1 transcription elongation regulator 1 10915 ENSG00000113649


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=7; E=2.80; R=2.50; rawP=0.0227; adjP=0.0318
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000112309 NA B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) 135152 ENSG00000112309
2  ENSG00000240038 NA AMY2B amylase, alpha 2B (pancreatic) 280 ENSG00000240038
3  ENSG00000135423 NA GLS2 glutaminase 2 (liver, mitochondrial) 27165 ENSG00000135423
4  ENSG00000108474 NA PIGL phosphatidylinositol glycan anchor biosynthesis, class L 9487 ENSG00000108474
5  ENSG00000256525 NA POLG2 polymerase (DNA directed), gamma 2, accessory subunit 11232 ENSG00000256525
6  ENSG00000129167 NA TPH1 tryptophan hydroxylase 1 7166 ENSG00000129167
7  ENSG00000072682 NA P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 8974 ENSG00000072682


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=2; E=0.33; R=5.97; rawP=0.0446; adjP=0.0520
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000185019 NA UBOX5 U-box domain containing 5 22888 ENSG00000185019
2  ENSG00000151876 NA FBXO4 F-box protein 4 26272 ENSG00000151876


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=2; E=0.81; R=2.47; rawP=0.1940; adjP=0.1940
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000131323 NA TRAF3 TNF receptor-associated factor 3 7187 ENSG00000131323
2  ENSG00000134245 NA WNT2B wingless-type MMTV integration site family, member 2B 7482 ENSG00000134245




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).